NEW YORK (Reuters Health) - When daily nasal saline irrigation for relief of rhinosinusitis is continued for more than about 2 to 6 weeks, it's actually likely to promote recurrent sinus disease.
That's according to a presentation Sunday by Dr. Talal M. Nsouli at the annual scientific meeting of the American College of Allergy, Asthma and Immunology in Miami Beach.
"We noticed a large number of patients were referred to our Watergate Allergy and Asthma Center (Washington, DC) for possible diagnoses of immune deficiency because they were experiencing frequent sinus infections. The common denominator in these patients was the daily use of nasal saline irrigation for a long-term period," Dr. Nsouli told Reuters Health.
"Nasal secretions contain very important immune elements, such as immunoglobulin A, IgG, lactoferrin, lysozyme, alpha and beta defensins, only to name a few," he explained. "Our hypothesis was that long-term daily (saline irrigation) may deplete the nose of its 'immune blanket' known to have antibacterial, antiviral, and antifungal activity, resulting in recurrent sinus infections."
In 68 adults with recurrent sinus disease, Dr. Nsouli and his associates evaluated the effect of discontinuing long-term daily irrigation by comparing the frequency of rhinosinusitis episodes 12 months before and 12 months after discontinuation. The frequency of acute rhinosinusitis episodes fell by 62.5% after discontinuation, they found.
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That's according to a presentation Sunday by Dr. Talal M. Nsouli at the annual scientific meeting of the American College of Allergy, Asthma and Immunology in Miami Beach.
"We noticed a large number of patients were referred to our Watergate Allergy and Asthma Center (Washington, DC) for possible diagnoses of immune deficiency because they were experiencing frequent sinus infections. The common denominator in these patients was the daily use of nasal saline irrigation for a long-term period," Dr. Nsouli told Reuters Health.
"Nasal secretions contain very important immune elements, such as immunoglobulin A, IgG, lactoferrin, lysozyme, alpha and beta defensins, only to name a few," he explained. "Our hypothesis was that long-term daily (saline irrigation) may deplete the nose of its 'immune blanket' known to have antibacterial, antiviral, and antifungal activity, resulting in recurrent sinus infections."
In 68 adults with recurrent sinus disease, Dr. Nsouli and his associates evaluated the effect of discontinuing long-term daily irrigation by comparing the frequency of rhinosinusitis episodes 12 months before and 12 months after discontinuation. The frequency of acute rhinosinusitis episodes fell by 62.5% after discontinuation, they found.
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